The information listed below is references to settings obtained from other mining channels.
Update and configure your motherboard at your own risk.
 

The first step to take, first of all: update the motherboard BIOS version to the latest firmware from the manufacturer.
You must extract the BIOS firmware .zip file for the correct motherboard brand/model onto your spare USB drive.

If you still have network connectivity issues or are unable to boot successfully with multiple GPUs, try these steps:

• When making any changes to your settings, be sure to change them one thing at a time.
• If you have a lot of GPUs, make sure no GPUs are directly connected to any 16x slots. Risers must be used for all GPUs.
• Unplug all GPUs except gpu0 (ignore all 1x slots, gpu0 is always the 16x PCI-E slot physically closest to the motherboard CPU socket).
• If your motherboard has onboard molex or PCI-E connectors, make sure you connect the correct cable to them.
• Check all your cables again. The first thing to check is your BIOS options. Normally you have to press DELETE as soon as your device is turned on to access the motherboard BIOS. Then go and set as many of these options as you can find:

AMD Motherboards
Define how many of these options you can find:

• Set IOMMU to ENABLED
• Set CSM to DISABLED.
• Set CPU UNLOCK to ENABLED (this may prevent the CPU temperature from being read correctly)
• Set COOL AND QUIET to DISABLED
• Set ONBOARD AUDIO / SOUND to DISABLED
• Set IEEE1394 to DISABLED
• Set APU ONBOARD GRAPHICS to DISABLED.

Intel Motherboards
Define how many of these options you can find:

• Set VT-d INTEL VIRTUALIZATION to DISABLED
• Set ONBOARD AUDIO / SOUND (AZALIA) to DISABLED
• Set IEEE1394 to DISABLED
• Set SUBSYSTEM / LANES PCI-E to x8 / x4 / x4
• Set ONBOARD GRAPHICS to DISABLED
• Set PCI-E GENERATION to GEN2.

• Save changes and restart. Let the device boot completely with just one GPU, then add more.

Enabling + GPUs

Follow the guide below if you have problems booting with 3 or + GPUs.

ASROCK Motherboards

Advanced -> Chipset settings -> change TOLUD to 3.5 GB

Advanced -> set "4G Decode" to ENABLED

Advanced -> set Re-Size BAR Support to ENABLED

Set all PCI-E settings to AUTO

ASUS Motherboards

Advanced mode (F7) -> "Boot" section -> set "4G Decode" to ENABLED

Set Re-Size BAR Support to ENABLED

In "Boot" -> set FAST BOOT to DISABLED

Under "Advanced" -> Onboard Devices Configuration -> set HD AUDIO CONTROLLER to DISABLED

Under "Advanced" -> PCH Configuration -> set PCI-E Link Speed ​​to GEN2

Note: Some users have reported that by enabling Advanced - Graphics configuration - IGFX Multi-monitor "Enabled" they were able to place more GPUs

Note: Some users have reported that GEN1 works better with ASUS PRIME Z270P. Try this if you have this card.

Biostar Motherboards

Under "Chipset" -> System Agent -> Above 4g ENABLED

Under "Chipset" -> System Agent -> set Re-Size BAR Support to ENABLED

Under "Chipset" -> PCi Express Configuration -> set PCI-E Link Speed ​​to GEN2

Under "Chipset" -> PCH-IO Configuration -> set HD AUDIO to DISABLED

Gigabyte Motherboards

Gigabyte has a specific hotsite for their motherboard configurations and provides compatibility information for the number of video cards on their chipsets.
https://www.gigabyte.com/MicroSite/462/mining.html

Update BIOS to F9d version (if chipset is supported)

Enable mining mode in Bios (if there is option in your Bios after upgrade)

Disable CSM option. To do this, leave the Windows 8/10 Features option, the CSM option will appear below

Change Link from PCIe to Gen2

Change display from PCI-e to IGFX

Enable 4G Decoding option

Set Re-Size BAR Support to ENABLED

MSI Motherboards

Under "Windows OS Configuration" -> set WINDOWS 7 INSTALLATION MODE to DISABLE and FAST BOOT to DISABLED

Under "Integrated Peripherals: -> set HD AUDIO CONTROLLER to DISABLED

Advanced Mode (F7) -> Settings -> Advanced Settings -> PCI-E Subsystem Settings ->

• set 4G DECODE to ENABLED
• set Re-Size BAR Support to ENABLED
• set PEG1 to "GEN 2"
• set PEG2 to "GEN 2"

If you are running this GPU on an Intel motherboard, you may experience boot problems in certain cases. Here are some suggestions:

• Do not use this GPU in the gpu0 slot. Instead, use another GPU.
• Use a 16x16x tape riser in the gpu0 slot.